During the holidays of Christmas, three groups of funny characters depart from Italy to spend the Christmas season in New York City.

Carlo, on vacation in South Africa with his second wife Susanna meets her younger brother Giorgio.

Destinies intertwined for two antithetical people who meet during a trip to India, where lots of misunderstandings and funny situations will take place.

In Christmastime Miami, heartbroken divorcée Giorgio invites himself to stay at his best friend Mario's — unaware that the latter is having an affair with his ex-wife — and ends up pursued by Mario's barely-of-age daughter; nosy and out-of-touch Ranuccio crashes his son's sex-themed holidays before ending up in a series of mishaps with Giorgio.

Fabio is in love with his colleague Linda, but she has never even seen him until he's mistaken for her boyfriend. Paolo and Mario leave for a luxurious vacation in Rio de Janeiro for Christmas, without knowing that their sons have booked a trip for the same low-cost destination and, for a problem of homonymy between fathers and sons, the two holidays are exchanged.

During the Christmas holidays, in Cortina d'Ampezzo interweave three stories.

Tommaso and Pietro are two brothers who, shortly after their father's funeral, discover that the coffin is actually empty. To find out more they leave for Malaysia, where the man died, but a series of misunderstandings and false clues will take them around the world to discover other empty coffins and a father yet to be found and perhaps to know.

A 'greatest hits' clip show of 35 years of Cinepanettoni, paying homage to the genre and its protagonists as a whole.

A chef who yearns for an international reputation helps his son try to win back his ex by arranging to cater her St. Moritz wedding to another man.

A very extended family gathers for the Christmas holidays, after the death of the breadwinner Leonardo Sereni, famous singer. The eldest son Julius, with his wife Marina, has a panettone factory.

A middle-aged man’s relationship with a young model is questioned by his daughter, who’s dating an older man herself.

In the barracks of the "Settecamini" fire brigade in Rome, the shabby Squadra 17 tackles missions with resounding failures, waiting in vain for a chance for redemption.

While on holiday in the Caribbean, a bankrupt family pins their hopes on a rich man, two strangers fall in lust, and a technophile gets shipwrecked.

Milanese and Naples people go to Cortina d'Ampezzo on Christmas holidays

A womanizing lawyer follows his wife and son to a trip to Egypt in a last-ditch effort to make up for his infidelities. Also travelling to Egypt is a bumbling police chief who's desperate to keep his rebellious daughter from becoming a showgirl. The two meet during a Nile cruise. Calamity ensues.

A good-natured but unlucky Italian is constantly going on a difficult situations, but never lose his mood.

Nicolas has a happy existence, parents who love him, a great group of friends with whom he has great fun, and all he wants is that nothing changes. However, one day, he overhears a conversation that leads him to believe that his life might change forever, his mother is pregnant! He panics and envisions the worst.